DNA mismatch repair deficiency as a biomarker in sarcoma
While rare, sarcoma can be encountered in patients with LS, particularly those with germline <i>MSH2</i> mutation. LS-associated sarcomas occur significantly earlier, carry a favorable outcome, and demonstrate the potential for durable response with immunotherapy.
Authors
- Ravin Ratan (ORCID: https://orcid.org/0000-0002-4914-7922)
- Davis R. Ingram (ORCID: https://orcid.org/0000-0001-5967-1501)
- Ryan A. Denu (ORCID: https://orcid.org/0000-0001-9698-9201)
- Y. Nancy You (ORCID: https://orcid.org/0009-0006-9753-2450)
- Khalida Wani (ORCID: https://orcid.org/0000-0002-2383-3908)
- Alexander J. Lazar (ORCID: https://orcid.org/0000-0002-6395-4499)
- Christina Lynn Roland (ORCID: https://orcid.org/0000-0003-3400-0087)
- Christopher D Quintana-Perez
- Sintawat Wangsiricharoen (ORCID: https://orcid.org/0000-0003-3652-698X)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- University of Puerto Rico System (PR)
Publication Details
- Journal
- Surgical Oncology Insight
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1016/j.soi.2024.100091
- Citations
- 1
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- National Institutes of Health
- University of Texas MD Anderson Cancer Center