Oxone-Mediated Regioselective Oxy-iodination of 1-Aryl/Alkyl Butadienes Using TBAI
A simple, mild, and environmentally benign regioselective oxy-iodination of 1-aryl/alkyl butadienes has been developed. While styrenes have been explored previously, this work on dienes has been highly regioselective and metal-free in oxy-iodination following Markovnikov's rule. The oxy-iodination products were obtained in good to excellent yields using various co-solvents (H<sub>2</sub>O, MeOH, EtOH, AcOH, etc.). In addition, the halohydrins have been useful building blocks in the synthesis of various functionalized keto iodides and azido alcohols.
Authors
- Dnyaneshwar A. Gorve
- Rodney A. Fernandes (ORCID: https://orcid.org/0000-0001-8888-0927)
Institutions
- Indian Institute of Technology Bombay (IN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1021/acs.joc.4c01439
- Primary Topic
- Vanadium and Halogenation Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Council of Scientific and Industrial Research, India
- University Grants Commission