Molecular Editing of Toluene by Sequential <i>meta</i>-C–H/Benzylic C–N Deaminative Functionalizations
An approach to synthesizing structurally diverse toluene derivatives via sequential <i>meta</i>-C-H and benzylic C-N deaminative functionalization was developed by using a recyclable bifunctional directing template. The functionalized Katritzky salt intermediates are shown to be engaged in a wide range of carbon-carbon and carbon-heteroatom bond formation reactions. The synthetic utility of the strategy was demonstrated by late-stage functionalization of toloxatone.
Authors
- Zelin Liu (ORCID: https://orcid.org/0000-0002-3516-3999)
- Zhong Jin (ORCID: https://orcid.org/0000-0001-5722-7175)
- Xiaohua Xu
- Yifei Yan (ORCID: https://orcid.org/0000-0002-2742-217X)
- Zhiwei Jiang (ORCID: https://orcid.org/0009-0008-4866-9199)
- Siquan He
Institutions
- Nankai University (CN)
- Kashi University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1021/acs.orglett.4c02781
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China