Network pharmacology- and molecular docking-based investigation on the mechanism of action of Si-ni San in the treatment of depression combined with anxiety and experimental verification in adolescent rats
This study demonstrates that adolescent anxiety- and depression-like behavior induced by MS combined CUMS can be ameliorated by Si-ni San by improved inflammation in hippocampus via targeting TNF pathway and Nrf2 pathway, helping to reveal the mechanism of Si-ni San in treating adolescent depression combined with anxiety.
Authors
- Jinman Liu (ORCID: https://orcid.org/0000-0002-6421-7482)
- Chongkun Shen
- Mingan Wu (ORCID: https://orcid.org/0000-0001-5617-8981)
- Xulan Cui
- Chao Liang (ORCID: https://orcid.org/0000-0003-3487-9001)
- Jiawen Huang (ORCID: https://orcid.org/0000-0002-6443-2203)
- Zhiping Li (ORCID: https://orcid.org/0000-0001-6194-023X)
- Wei J. Chen (ORCID: https://orcid.org/0000-0001-5899-5870)
- Weirong Li (ORCID: https://orcid.org/0000-0002-3878-8724)
- Shimin Liang
- Zaibin Xu
Institutions
- Guangzhou University of Chinese Medicine (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
- Jiangmen Wuyi Traditional Chinese Medicine Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Hainan Provincial Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2024-08-23
- DOI
- https://doi.org/10.3389/fpsyt.2024.1414242
- Citations
- 7
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.10