Confirmation of Di(2-ethylhexyl) phthalate-induced micronuclei by repeated dose liver micronucleus assay: focus on evaluation of liver micronucleus assay in young rats
The detection of DEHP-induced micronuclei by the RDLMN assay suggests that this assay could detect the potential genotoxicity and hepatocarcinogenicity of DEHP. It also demonstrated the utility of the RDLMN assay in identifying metabolically activated hepatic carcinogens.
Authors
- Miyuki Shigano (ORCID: https://orcid.org/0000-0002-8191-8934)
- Kensuke Satomoto
- Rie Takashima
- Shuichi Hamada (ORCID: https://orcid.org/0000-0002-2211-8865)
- Henri Sales
- Ryoko Harada
Institutions
- NEC (Japan) (JP)
- Ishihara Sangyo Kaisha (Japan) (JP)
- Nippon Kayaku (Japan) (JP)
- BoZo Research Center (Japan) (JP)
Publication Details
- Journal
- Genes and Environment
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1186/s41021-024-00311-x
- Citations
- 3
- Primary Topic
- Effects and risks of endocrine disrupting chemicals
- Type
- article
- Field-Weighted Citation Impact
- 0.94