The Expression of Toll-like Receptors in Cartilage Endplate Cells: A Role of Toll-like Receptor 2 in Pro-Inflammatory and Pro-Catabolic Gene Expression
The expression of TLR1-10 in CEPCs suggests that the CEP is susceptible to PAMP and DAMP stimulation. Enhanced TLR2 expression in MC1, and generally in CEPCs under inflammatory conditions, has pro-inflammatory and pro-catabolic effects, suggesting a potential role in disc degeneration and MC.
Authors
- Roy Marcus (ORCID: https://orcid.org/0000-0002-5456-7366)
- Irina Heggli (ORCID: https://orcid.org/0000-0002-3064-8364)
- Nick Herger (ORCID: https://orcid.org/0000-0001-5369-9781)
- Mazda Farshad (ORCID: https://orcid.org/0000-0002-7190-1127)
- Ján Deván (ORCID: https://orcid.org/0009-0009-1544-7511)
- Oliver Distler (ORCID: https://orcid.org/0000-0002-0546-8310)
- Stefan Dudli (ORCID: https://orcid.org/0000-0001-7351-713X)
- Laura Bernhard
- Christine L. Le Maitre (ORCID: https://orcid.org/0000-0003-4489-7107)
- Florian Brunner (ORCID: https://orcid.org/0000-0002-1420-3824)
- Christoph Johannes Laux (ORCID: https://orcid.org/0000-0002-5446-3057)
- Tamara Mengis (ORCID: https://orcid.org/0009-0000-5595-5224)
- Andrea Nüesch (ORCID: https://orcid.org/0000-0002-0962-8705)
Institutions
- University of Zurich (CH)
- University Hospital of Zurich (CH)
- University of Sheffield (GB)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Cells
- Published
- 2024-08-23
- DOI
- https://doi.org/10.3390/cells13171402
- Citations
- 5
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 2.24
Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung