A novel method for cell deconvolution using DNA methylation in PCA space
Our study confirms the efficacy of cell type deconvolution in PCA space. The results indicate wide-ranging applicability and potential for adaptation to other forms of genomic data.
Authors
- Huan Xu (ORCID: https://orcid.org/0000-0002-2815-4322)
- Ge Zhang (ORCID: https://orcid.org/0000-0002-7807-7695)
- Jing Chen (ORCID: https://orcid.org/0009-0004-4504-7782)
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- March of Dimes (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- BMC Genomics
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1186/s12864-024-10652-0
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Burroughs Wellcome Fund
- Bill and Melinda Gates Foundation
- March of Dimes Prematurity Research Center Ohio Collaborative
- Eunice Kennedy Shriver National Institute of Child Health and Human Development