Dexamethasone inhibited angiotensin II and its receptors to reduce sepsis-induced lung and kidney injury in rats
Sepsis can cause acute lung and kidney injury and changes RAAS components in circulating, lung and renal. DXM can improve acute lung and kidney injury in septic rats, and the mechanism may be related to the down-regulation of inflammatory factors, AngII, AT2R, NO and up-regulation of AT1R expression by DXM.
Authors
- Haitao Bai (ORCID: https://orcid.org/0000-0002-8409-6163)
- Zhuqin Zhan (ORCID: https://orcid.org/0000-0003-1109-1502)
- Zhulan Lian
Institutions
- Xiamen University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Children’s Hospital of Fudan University Xiamen Branch (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1371/journal.pone.0308557
- Citations
- 6
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 2.04
Funders
- Xiamen University