A retrospective survey on the effectiveness of vaccines administered to individuals in China with regard to inactivated COVID-19 vaccines, Ad5-nCoV and/or aerosolized Ad5-nCoV
We administered a questionnaire to participants who received different vaccination regimens to evaluate the effectiveness of Ad5-vectored COVID-19 vaccines. The results showed that administration of intramuscular Ad5-nCoV provided 21.32% more protection against SARS-CoV-2 infection than that of the inactivated COVID-19 vaccine in people who had received only one type of COVID-19 vaccine. Furthermore, aerosolized Ad5-nCoV exhibited good protection, whether it was administered as a homologous booster to people vaccinated with the intramuscular Ad5-nCoV or as a heterologous booster to people vaccinated with inactivated COVID-19 vaccines. Our research indicates that Ad5-nCoV is an effective booster. This finding supports the future selection of COVID-19 immunization strategies.
Authors
- Wei Chen (ORCID: https://orcid.org/0000-0001-5805-2469)
- Lihua Hou (ORCID: https://orcid.org/0000-0001-7366-8974)
- Xiangyang Chi (ORCID: https://orcid.org/0000-0002-0580-5997)
- Zhe Zhang (ORCID: https://orcid.org/0000-0002-9303-8221)
- Jinlong Zhang (ORCID: https://orcid.org/0000-0001-9427-2645)
- Liangjun Li
- Mengjing Li
- Songhe Lu (ORCID: https://orcid.org/0009-0008-2142-0609)
- Fang-Ze Shao
- Guan-Ying Zhang
- Zhang Zhang (ORCID: https://orcid.org/0000-0001-6088-2293)
- Yue Zhang (ORCID: https://orcid.org/0000-0002-7786-0231)
Institutions
- University of Nottingham Ningbo China (CN)
- Shanghai Police College (CN)
- Chinese People's Armed Police Force
- Air Force Medical University (CN)
Publication Details
- Journal
- Emerging Microbes & Infections
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1080/22221751.2024.2396875
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.39