The RNA N6-methyladenosine demethylase FTO regulates ATG5 to inhibit malignant progression of uveal melanoma
Our research highlights the importance of the m6A demethylase FTO in UVM by demonstrating that it direct regulates ATG5-induced autophagy in an m6A-dependent manner. These findings suggest that FTO may serve as a potential therapeutic target for UVM.
Authors
- Yusheng Zhong
- Cheng Chi (ORCID: https://orcid.org/0000-0001-9143-7125)
- Jianhong Liang (ORCID: https://orcid.org/0000-0001-8695-2026)
- Ya-Ting Yang (ORCID: https://orcid.org/0000-0001-8512-5336)
- Xun Deng
- Xuemei Zhu
- Xiacheng Lin
- Yong Cheng
Institutions
- Peking University (CN)
- Peking University People's Hospital (CN)
Publication Details
- Journal
- Journal of Proteomics
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1016/j.jprot.2024.105282
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.23