Integrated multi-omics analyses reveal the pro-inflammatory and pro-fibrotic pulmonary macrophage subcluster in silicosis
Our study suggested that a group of Mmp12<sup>hi</sup> macrophages highly express both pro-inflammatory and pro-fibrotic factors in silicosis mice, and thus may contribute to the progression of fibrosis. The findings have proposed new insights for understanding the heterogeneity of lung macrophages in silicosis, suggesting that the subset of Mmp12<sup>hi</sup> macrophages may be a potential therapy target to further halt the progression of silicosis.
Authors
- Siyu Cao (ORCID: https://orcid.org/0000-0002-4886-7071)
- Nan Song (ORCID: https://orcid.org/0000-0002-7442-7475)
- Xueqing Gu
- Hanyujie Kang
- Zhaohui Tong (ORCID: https://orcid.org/0000-0002-5341-6857)
Institutions
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1016/j.ecoenv.2024.116899
- Citations
- 8
- Primary Topic
- Occupational and environmental lung diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.35