TBHP Promotes Cross-Dehydrogenative Coupling of SF<sub>4</sub> Alkynes with Tetrahydroisoquinolines under Copper Catalysis
We present a viable approach for the cross-dehydrogenative coupling of Het-SF<sub>4</sub>-alkynes with tetrahydroisoquinolines under oxidative conditions, using TBHP and copper catalysts. These newly developed conditions boast enhanced yields and a more extensive range of substrates, demonstrating tolerance to various functional groups and addressing the limitations of earlier reports. Consequently, this method should increase opportunities for the exploration of SF<sub>4</sub>-containing compounds and their potential applications in drug discovery, materials science, and as alternatives to PFAS.
Authors
- Srikanth Reddy Narra
- Muhamad Zulfaqar Bacho (ORCID: https://orcid.org/0000-0002-6595-7490)
- Debarshi Saha (ORCID: https://orcid.org/0000-0001-7434-1981)
- Norio Shibata (ORCID: https://orcid.org/0000-0002-3742-4064)
- Putri Nur Arina Mohd Ariff
Institutions
- Nagoya Institute of Technology (JP)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1021/acs.orglett.4c02599
- Citations
- 4
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.00
Funders
- Core Research for Evolutional Science and Technology