Treatment of prolonged seizure with diazepam nasal spray: An exploratory post hoc cohort analysis
Although immediate use of diazepam nasal spray (within 5 min) resulted in quicker seizure termination, a treatment delay of 5 to 15 min still produced rapid termination of the seizure cluster with high first-dose effectiveness and an overall acceptable safety profile. These findings suggest that diazepam nasal spray maintains effectiveness in prolonged seizures within a cluster with delayed treatment.
Authors
- Randa Jarrar (ORCID: https://orcid.org/0000-0001-9373-0579)
- Danielle A. Becker (ORCID: https://orcid.org/0000-0002-4792-8055)
- Enrique J. Carrazana (ORCID: https://orcid.org/0000-0001-8788-0722)
- John M. Stern (ORCID: https://orcid.org/0000-0002-3549-1642)
- Adrián L. Rabinowicz (ORCID: https://orcid.org/0000-0003-1299-0606)
- Charles S. Davis
Institutions
- Eurostat (LU)
- University of California, Los Angeles (US)
- The Ohio State University Wexner Medical Center (US)
- Phoenix Children's Hospital (US)
- Neurelis (United States) (US)
- Florida Atlantic University (US)
Publication Details
- Journal
- Epilepsy & Behavior
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1016/j.yebeh.2024.109987
- Citations
- 3
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.16