Interaction of milrinone with extracorporeal life support
Milrinone dosing adjustments are likely required in patients who are supported with CRRT while dosing adjustments for ECMO based on these ex-vivo results are likely unnecessary. These results will help improve the safety and efficacy of milrinone in patients requiring ECMO and CRRT. Due to the limitations of ex-vivo experiments, future studies of milrinone exposure with ECLS should include patient circuit interactions as well as the physiology of critical illness.
Authors
- Aviva Whelan (ORCID: https://orcid.org/0000-0001-8968-3183)
- Kevin Watt (ORCID: https://orcid.org/0000-0002-5975-5091)
- J. Porter Hunt (ORCID: https://orcid.org/0000-0003-3503-8124)
- Autumn McKnite (ORCID: https://orcid.org/0000-0001-7985-2991)
- Danielle Greene (ORCID: https://orcid.org/0000-0001-6924-3797)
- Gideon A. Stitt (ORCID: https://orcid.org/0000-0001-5269-214X)
- Jeremiah D. Momper (ORCID: https://orcid.org/0000-0002-3154-6685)
- Carina Imburgia
- Sabiha Mim
Institutions
- Uppsala University (SE)
- University of Utah (US)
- University of Montana (US)
Publication Details
- Journal
- Journal of ExtraCorporeal Technology
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1051/ject/2024014
- Primary Topic
- Mechanical Circulatory Support Devices
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ohio State University
- National Heart, Lung, and Blood Institute
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development