Docosahexaenoic acid insufficiency impairs placental angiogenesis by repressing the methylene-bridge fatty acylation of AKT in preeclampsia
Our results suggest that placental DHA insufficiency downregulates placental angiogenesis via inhibiting fatty acylating AKT and AKT-VEGFA signalling, a novel insight into abnormal fatty acid metabolism in PE.
Authors
- Yutong Cui (ORCID: https://orcid.org/0000-0002-5929-5101)
- Lidong Liu
- Yiyuan Yuan (ORCID: https://orcid.org/0000-0003-0829-3824)
- Huiqing Lu (ORCID: https://orcid.org/0000-0002-6636-0338)
- Huanqiang Zhao (ORCID: https://orcid.org/0000-0002-3664-8031)
- Yu Xiong (ORCID: https://orcid.org/0000-0002-6765-459X)
- Yinan Wang (ORCID: https://orcid.org/0000-0001-8714-2105)
- Xiaotian Li (ORCID: https://orcid.org/0000-0002-2051-4581)
- Xirong Xiao (ORCID: https://orcid.org/0000-0002-6949-055X)
- Shimin Zhao
- Qiongjie Zhou
Institutions
- Fudan University (CN)
- Shenzhen Maternity and Child Healthcare Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- Children's Hospital of Fudan University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Placenta
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1016/j.placenta.2024.08.012
- Citations
- 2
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 1.17