The persistence of low CD4/CD8 ratio in chronic HIV-infection, despite ART suppression and normal CD4 levels, is associated with pre-therapy values of inflammation and thymic function
Persistence of low CD4/CD8 ratio in successfully-treated PLWH, with normal CD4 counts, is associated with baseline inflammation and low thymic function, and it features post-therapy alterations specific to CD8 T-cells. Differently, subjects recovered from low nadir-CD4 in this setting feature post-therapy alterations on CD4 T-cells. Hence, different mechanisms of disease progression could underlie these biomarkers, potentially requiring different clinical approaches.
Authors
- Rebeca Izquierdo (ORCID: https://orcid.org/0000-0001-5780-4462)
- Anna Rull (ORCID: https://orcid.org/0000-0002-8907-7754)
- Vanesa Garrido‐Rodríguez (ORCID: https://orcid.org/0000-0002-0031-1437)
- Félix Gutiérrez (ORCID: https://orcid.org/0000-0002-9485-6867)
- Yolanda M. Pacheco (ORCID: https://orcid.org/0000-0002-9451-8083)
- Féderico García (ORCID: https://orcid.org/0000-0001-7611-781X)
- Juan Tiraboschi (ORCID: https://orcid.org/0000-0002-0073-873X)
- María del Mar Pozo‐Balado
- Ángel Bulnes‐Ramos (ORCID: https://orcid.org/0000-0003-3118-9419)
- Francisco Jesús Vera-Méndez
- Israel Olivas‐Martínez
- Ana Isabel Álvarez‐Ríos (ORCID: https://orcid.org/0000-0003-2394-0890)
- Joaquim Peraire
Institutions
- Universitat de Miguel Hernández d'Elx (ES)
- Instituto de Salud Carlos III (ES)
- Bellvitge University Hospital (ES)
- Institut de Recerca Biomèdica Catalunya Sud (ES)
- Instituto de Investigación Biosanitaria de Granada (ES)
- Instituto de Biomedicina de Sevilla (ES)
- Santa Lucía University General Hospital (ES)
- Hospital Universitario Virgen del Rocío (ES)
Publication Details
- Journal
- Journal of Microbiology Immunology and Infection
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1016/j.jmii.2024.08.007
- Citations
- 5
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Ministerio de Ciencia, Innovación y Universidades
- Consejería de Transformación Económica, Industria, Conocimiento y Universidades
- Centro Pfizer-Universidad de Granada-Junta de Andalucía de Genómica e Investigación Oncológic
- Instituto de Salud Carlos III