Baseline Viral Load and On-Treatment Hepatocellular Carcinoma Risk in Chronic Hepatitis B: A Multinational Cohort Study
Baseline viral load showed a significant, non-linear, parabolic association with HCC risk during antiviral treatment in noncirrhotic patients with CHB. Early initiation of antiviral treatment based on HBV viral load may help prevent irreversible HCC risk accumulation in patients with CHB.
Authors
- Jung Woo Shin (ORCID: https://orcid.org/0000-0001-7001-0341)
- Young‐Joo Jin (ORCID: https://orcid.org/0000-0002-7449-2461)
- Leland J. Yee (ORCID: https://orcid.org/0000-0002-0369-5878)
- Terry Cheuk‐Fung Yip (ORCID: https://orcid.org/0000-0002-1819-2464)
- Hyun Phil Shin (ORCID: https://orcid.org/0000-0002-9350-1079)
- Neung Hwa Park (ORCID: https://orcid.org/0000-0002-5648-9189)
- Dae Won Jun (ORCID: https://orcid.org/0000-0002-2875-6139)
- Laura J. Clark (ORCID: https://orcid.org/0000-0003-4378-2420)
- Tristan Curteis
- Zarena Jafry (ORCID: https://orcid.org/0000-0001-9428-4793)
- Chi-Yi Chen (ORCID: https://orcid.org/0000-0002-5438-2871)
- Cheng‐Yuan Peng (ORCID: https://orcid.org/0000-0001-9030-6086)
- Yi‐Hsiang Huang (ORCID: https://orcid.org/0000-0001-5241-5425)
- Yao‐Hsu Yang (ORCID: https://orcid.org/0000-0002-8080-0504)
- Won‐Mook Choi (ORCID: https://orcid.org/0000-0002-9158-1765)
- Young‐Suk Lim (ORCID: https://orcid.org/0000-0002-1544-577X)
- Grace Lai–Hung Wong (ORCID: https://orcid.org/0000-0002-2863-9389)
- C. Brooks-Rooney
- W. Ray Kim (ORCID: https://orcid.org/0000-0002-3030-860X)
- Chien‐Hung Chen (ORCID: https://orcid.org/0000-0002-8896-8133)
- Jin‐Wook Kim (ORCID: https://orcid.org/0000-0003-0934-3344)
Institutions
- Ulsan College (KR)
- Seoul National University (KR)
- National Yang Ming Chiao Tung University (TW)
- Chang Gung University (TW)
- Chinese University of Hong Kong (HK)
- China Medical University (TW)
- Asan Medical Center (KR)
- Taipei Veterans General Hospital (TW)
- Seoul National University Bundang Hospital (KR)
- University of Ulsan (KR)
- Kaohsiung Chang Gung Memorial Hospital (TW)
- Chia-Yi Christian Hospital (TW)
- China Medical University Hospital (TW)
- Ulsan University Hospital (KR)
- Gilead Sciences (United States) (US)
- Hanyang University Seoul Hospital (KR)
- Kyung Hee University Hospital at Gangdong (KR)
- Inha University Hospital (KR)
- Chiayi Chang Gung Memorial Hospital (TW)
- Costello Medical Consulting (United Kingdom) (GB)
- National Yang Ming Chiao Tung University (TW)
- Stanford University (US)
Publication Details
- Journal
- Clinical Gastroenterology and Hepatology
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1016/j.cgh.2024.07.031
- Citations
- 11
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.25
Funders
- Gilead Sciences