LAIR-1 and PECAM-1 function via the same signaling pathway to inhibit GPVI-mediated platelet activation
Findings from this study reveal that LAIR-1 and PECAM-1 act to inhibit GPVI-mediated platelet activation via the same signaling pathway. Mice lacking LAIR-1 and PECAM-1 do not however exhibit an increase in thrombus formation despite minor increase in platelet count and reactivity to collagen. This study adds to the growing evidence that immunoreceptor tyrosine-based inhibition motif-containing receptors are important regulators of platelet count and function.
Authors
- Zoltán Nagy (ORCID: https://orcid.org/0000-0001-6517-2071)
- Jeremy A. Pike (ORCID: https://orcid.org/0000-0003-4163-0335)
- Alexandra Mazharian (ORCID: https://orcid.org/0000-0002-0204-3325)
- Pushpa Patel (ORCID: https://orcid.org/0000-0001-8181-6682)
- Mitchell J. Geer (ORCID: https://orcid.org/0000-0003-1457-987X)
- Yotis A. Senis (ORCID: https://orcid.org/0000-0002-0947-9957)
- Christopher W. Smith
Institutions
- Inserm (FR)
- University of Würzburg (DE)
- NYU Langone Health (US)
- Établissement Français du Sang (FR)
- University of Birmingham (GB)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1016/j.rpth.2024.102557
- Citations
- 6
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.73
Funders
- British Heart Foundation
- Medical Research Council