Brain volumes and cortical thickness and associations with cognition in children born extremely preterm
This study investigated brain volumes, volumetric growth, and cortical thickness in children born extremely preterm, who have rarely been studied exclusively, and compared the data with term-born controls. In both groups, brain volumes at 10 years were positively associated with cognitive outcome at 12 years, but cortical thickness at 10 years was negatively associated with cognitive outcome at 12 years. Volumetric growth from term age to 10 years was not associated with cognitive outcome in the subset of children born extremely preterm with longitudinal data. Insular volume may be a potential biomarker for cognitive outcome in children born extremely preterm.
Authors
- Lina Broström (ORCID: https://orcid.org/0000-0002-5585-5749)
- Hedvig Kvanta (ORCID: https://orcid.org/0000-0003-3557-9000)
- Daniela Nosko (ORCID: https://orcid.org/0000-0001-7025-4661)
- Gustaf Mårtensson (ORCID: https://orcid.org/0000-0002-6041-4980)
- Lexuri Fernández de Gamarra‐Oca (ORCID: https://orcid.org/0000-0003-1593-6787)
- Nelly Padilla (ORCID: https://orcid.org/0000-0002-7428-2691)
- Jenny Bolk (ORCID: https://orcid.org/0000-0002-4240-261X)
- Ulrika Ådén (ORCID: https://orcid.org/0000-0002-0650-3173)
Institutions
- Universidad de Deusto (ES)
- Karolinska Institutet (SE)
- Stockholm South General Hospital (SE)
- Örebro University Hospital (SE)
Publication Details
- Journal
- Pediatric Research
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1038/s41390-024-03480-1
- Citations
- 4
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 4.44
Funders
- Karolinska Institutet
- Stockholms Läns Landsting
- Svenska Läkaresällskapet
- Sällskapet Barnavård
- Medical Research Council