A core proteome profile unites mouse models and patients in Alzheimer disease
Levites et al. demonstrate that mouse models of Alzheimer disease (AD), exhibiting amyloid-beta (Αβ) plaque formation, share Αβ responsome proteins with humans. Their work underscores the value of these models in studying Αβ aggregation, cellular vulnerability, and early-stage AD pathology.
Authors
- Frédéric Rousseau (ORCID: https://orcid.org/0000-0002-9189-7399)
- Joost Schymkowitz (ORCID: https://orcid.org/0000-0003-2020-0168)
- Grigoria Tsaka
Institutions
- VIB-KU Leuven Center for Brain & Disease Research (BE)
Publication Details
- Journal
- Cell Reports Medicine
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1016/j.xcrm.2024.101683
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- Vlaams Instituut voor Biotechnologie
- Vlaamse regering