Thiostrepton induces spindle abnormalities and enhances Taxol cytotoxicity in MDA-MB-231 cells
These results suggest that, in addition to inhibiting FoxM1, TST may induce proteotoxicity and autophagy to disrupt cellular tubulin polymerization, and this mechanism might account for its antimitotic effects, enhancement of Taxol anticancer effects, and ability to overcome Taxol resistance in MDA-MB-231 cells. These data further imply that TST may be useful to improve the therapeutic efficacy of Taxol.
Authors
- Ling‐Huei Yih (ORCID: https://orcid.org/0000-0002-0693-5590)
- Jhong-Syuan Yao
- Hsiao‐Hui Kuo
Institutions
- Institute of Cellular and Organismic Biology, Academia Sinica (TW)
Publication Details
- Journal
- Molecular Biology Reports
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1007/s11033-024-09863-1
- Citations
- 1
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Academia Sinica
- National Science and Technology Council