Different diabetogenic effect of statins according to intensity and dose in patients with acute myocardial infarction: a nationwide cohort study

Statin is crucial for acute myocardial infarction (AMI) patients. However, the risk of new-onset diabetes mellitus (NODM) associated with statin is a concern. This study aimed to determine the incremental diabetogenic effects of statins according to their intensity and dose in AMI patients undergoing percutaneous coronary intervention (PCI). Among 13,104 patients enrolled in the Korea AMI Registry between 2011 and 2015, 6152 patients without diabetes mellitus (DM) who underwent PCI and received moderate-to-high-intensity atorvastatin and rosuvastatin were selected for the study. The endpoints were NODM and major adverse cardiovascular events (MACE), composite of all-cause mortality, recurrent MI, and revascularization up to 3 years. Among the participants, 3747 and 2405 received moderate- and high-intensity statins, respectively. The Kaplan-Meier curves demonstrated a higher incidence of NODM in patients with high-intensity statins than those with moderate-intensity. High-intensity statin was a significant predictor of NODM after adjusting for other co-variables (HR = 1.316, 95% CI 1.024-1.692; P < 0.032). Higher dose of rosuvastatin was associated with a higher cumulative incidence of NODM, but this dose-dependency was not apparent with atorvastatin. Cumulative incidence of MACE decreased dose-dependently only with atorvastatin. High-intensity statin was associated with a higher cumulative incidence of NODM in AMI patients, and this association was more evident in rosuvastatin. The different diabetogenic effects of the two statins provide supporting evidence for understanding the nuanced nature of statin treatment in relation to NODM.

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Publication Details

Journal
Scientific Reports
Published
2024-08-21
DOI
https://doi.org/10.1038/s41598-024-67585-7
Citations
2
Primary Topic
Lipoproteins and Cardiovascular Health
Type
article
Field-Weighted Citation Impact
1.15

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article

Different diabetogenic effect of statins according to intensity and dose in patients with acute myocardial infarction: a nationwide cohort study

Dong Oh Kang, Jin Oh Na, Jei Keon Chae, Seok Kyu Oh et al.
2 citations
Scientific Reports
Lipoproteins and Cardiovascular Health
1.15
article

Different diabetogenic effect of statins according to intensity and dose in patients with acute myocardial infarction: a nationwide cohort study

Dong Oh Kang, Jin Oh Na, Jei Keon Chae, Seok Kyu Oh, Eung Ju Kim, Kwang Soo, Jah Yeon Choi, Seung‐Jae Joo, Seung‐Ho Hur, Hyo‐Soo Kim, Seung‐Young Roh, Chang‐Hwan Yoon, Jin‐Yong Hwang, Ji Bak Kim, Hyeon‐Cheol Gwon, Kyung‐Kuk Hwang, Jin‐Ok Jeong, Tae Hoon Ahn, Shung Chull Chae, Ki Bae Seung, In Whan Seong, Jieun Lee, Soohyung Park, Chang Gyu Park, Seung‐Jun Lee, Myung Ho Jeong, Eun Jin Park, Chong‐Jin Kim, You-Jung Choi, Doo‐Il Kim, Byoung Geol Choi, Cheol Ung Choi, Seok‐Kyu Oh, Junghan Yoon
article en
2 citations

Abstract

Statin is crucial for acute myocardial infarction (AMI) patients. However, the risk of new-onset diabetes mellitus (NODM) associated with statin is a concern. This study aimed to determine the incremental diabetogenic effects of statins according to their intensity and dose in AMI patients undergoing percutaneous coronary intervention (PCI). Among 13,104 patients enrolled in the Korea AMI Registry between 2011 and 2015, 6152 patients without diabetes mellitus (DM) who underwent PCI and received moderate-to-high-intensity atorvastatin and rosuvastatin were selected for the study. The endpoints were NODM and major adverse cardiovascular events (MACE), composite of all-cause mortality, recurrent MI, and revascularization up to 3 years. Among the participants, 3747 and 2405 received moderate- and high-intensity statins, respectively. The Kaplan-Meier curves demonstrated a higher incidence of NODM in patients with high-intensity statins than those with moderate-intensity. High-intensity statin was a significant predictor of NODM after adjusting for other co-variables (HR = 1.316, 95% CI 1.024-1.692; P < 0.032). Higher dose of rosuvastatin was associated with a higher cumulative incidence of NODM, but this dose-dependency was not apparent with atorvastatin. Cumulative incidence of MACE decreased dose-dependently only with atorvastatin. High-intensity statin was associated with a higher cumulative incidence of NODM in AMI patients, and this association was more evident in rosuvastatin. The different diabetogenic effects of the two statins provide supporting evidence for understanding the nuanced nature of statin treatment in relation to NODM.

Scientific ReportsVol. 14(1)
Korea University Medical Center (KR), Kyungpook National University Hospital (KR), Samsung Medical Center (KR), Seoul National University Hospital (KR), Seoul National University Bundang Hospital (KR), Gachon University Gil Medical Center (KR), Gyeongsang National University Hospital (KR), Chonnam National University Hospital (KR), Inje University Haeundae Paik Hospital (KR), Wonju Severance Christian Hospital (KR), Pusan National University Hospital (KR), Keimyung University Dongsan Medical Center (KR), Jeonbuk National University Hospital (KR), Chungnam National University Hospital (KR), Yeungnam University Medical Center (KR), Kyung Hee University Hospital at Gangdong (KR), The Catholic University of Korea Seoul St. Mary's Hospital (KR), Chungbuk National University Hospital (KR), Jeju National University Hospital (KR), Keimyung University (KR), Wonkwang University (KR)
Korea University
Good health and well-being
Openalex Percentile: Top 21%
Lipoproteins and Cardiovascular Health
1.15
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