Modulation of PD-L1 by Astragalus polysaccharide attenuates the induction of melanoma stem cell properties and overcomes immune evasion
APS inhibited MSC induction and overcame tumor immune evasion through reducing PD-L1 expression. This study provided compelling evidence that APS could be a prospective therapeutic agent for treating melanoma.
Authors
- Xi Qiao (ORCID: https://orcid.org/0000-0002-5264-3425)
- Qianyi Gong (ORCID: https://orcid.org/0000-0002-3082-345X)
- Guiqing Ding (ORCID: https://orcid.org/0000-0003-1612-9506)
- Yuanhua Wang (ORCID: https://orcid.org/0000-0003-4692-325X)
- Hua Yu (ORCID: https://orcid.org/0000-0003-3149-1941)
- Yan Zhao (ORCID: https://orcid.org/0000-0002-3365-5877)
- Jinyun Ma (ORCID: https://orcid.org/0000-0003-4130-4484)
- Xiaodong Cheng (ORCID: https://orcid.org/0000-0003-3909-7308)
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Yueyang Hospital (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1186/s12885-024-12788-4
- Citations
- 11
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.11
Funders
- National Natural Science Foundation of China
- Shanghai University of Traditional Chinese Medicine