Modular, Scalable Total Synthesis of Neopetromin<sup>†</sup>
Comprehensive Summary The first total synthesis of neopetromin, featuring the highly strained Tyr C‐6‐to‐Trp N‐1’ linkage, is hereby reported. This modular synthetic strategy, employing C—H arylation and Larock macrocyclization, offers a novel approach to the synthesis of various RiPPs natural product families.
Authors
- Hugh Nakamura (ORCID: https://orcid.org/0000-0001-5475-7883)
- Yuuya Nagata (ORCID: https://orcid.org/0000-0001-5926-5845)
- Hiroshige Ogawa
Institutions
- Hong Kong University of Science and Technology (HK)
- Hokkaido University (JP)
- University of Hong Kong (HK)
Publication Details
- Journal
- Chinese Journal of Chemistry
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1002/cjoc.202400637
- Citations
- 7
- Primary Topic
- Marine Sponges and Natural Products
- Type
- article
- Field-Weighted Citation Impact
- 2.70
Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Hong Kong University of Science and Technology
- Japan Society for the Promotion of Science
- Exploratory Research for Advanced Technology