Potential molecular metabolic mechanisms underlying the effects of cimifugin in gastric cancer through single-cell and bulk RNA sequencing combined with network pharmacology
We verified the pharmacological effects of cimifugin on GC cell proliferation, invasion, and migration. AKR1C2, MAOB, and PDE2A were identified as the key targets of cimifugin in GC-related metabolic reprogramming and pathogenesis. Our research provides preliminary insights into the potential therapeutic effects of cimifugin, which could be considered for future exploration in the context of GC treatment.
Authors
- Jieying Wen (ORCID: https://orcid.org/0009-0002-7771-2586)
- Ziming Zhu (ORCID: https://orcid.org/0000-0001-6819-5754)
- Yinbiao Zhang (ORCID: https://orcid.org/0009-0008-6470-1419)
- Tao Zhang
- Shanneng Tang
- Xuan Zhou (ORCID: https://orcid.org/0009-0002-4221-8617)
- Yang Bai
- Xiao Li (ORCID: https://orcid.org/0009-0001-2912-0167)
- Xinyue Zhang (ORCID: https://orcid.org/0009-0001-0428-4616)
- Qiaoling Chen (ORCID: https://orcid.org/0009-0008-1381-5811)
Institutions
- Guangxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Gastrointestinal Oncology
- Published
- 2024-08-01
- DOI
- https://doi.org/10.21037/jgo-24-413
- Citations
- 5
- Primary Topic
- Bioactive Compounds and Antitumor Agents
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- Massachusetts Department of Agricultural Resources
- Natural Science Foundation of Guangxi Zhuang Autonomous Region
- Education Department of Guangxi Zhuang Autonomous Region
- Guangxi University
- Division of Graduate Education