The consistently up-regulated expression of NLRP3 in severe asthma patients from mRNA microarray and ovalbumin-induced mouse model of asthma
Through bioinformatics analysis, we identified a multitude of DEGs that could potentially contribute significantly to the development of SA. Notably, our findings highlight NLRP3 as a potential pivotal player in asthma pathogenesis, underscoring its prospective utility as a biomarker for SA.
Authors
- Zhongpeng Li
- Jian Wu (ORCID: https://orcid.org/0000-0002-3394-1507)
- Xiaowen Chen (ORCID: https://orcid.org/0000-0002-3353-7563)
- Jinle Lin
- Shaohua Luo (ORCID: https://orcid.org/0000-0002-4517-3728)
- Fang Wang (ORCID: https://orcid.org/0000-0001-7353-9080)
Institutions
- Sun Yat-sen University (CN)
- Peking University (CN)
- Fudan University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Peking University Sixth Hospital (CN)
- Shenzhen Second People's Hospital (CN)
- Southern Medical University (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Journal of Thoracic Disease
- Published
- 2024-08-01
- DOI
- https://doi.org/10.21037/jtd-24-567
- Citations
- 2
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.48
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Hainan Medical University