On drug therapy for an HIV infection age model with cellular and immune delays

We study the effectiveness of drug therapy for an HIV infection age mathematical model that considers both virus-to-cell and cell-to-cell infections, as well as the immune response. As expected, in the presence of perfect inhibitors, the populations of infected cells, virus, and effector cells decay exponentially to zero. When protease inhibitors are used, the production of infectious virions is diminished, as demonstrated in our drug therapy model. We begin our model analysis by proving the positivity and boundedness of the solutions, which are necessary conditions for the model's well-posedness. Our main result shows that, under a certain condition, both the infected cell population and the infectious virus decay exponentially to zero. For more information see https://ejde.math.txstate.edu/conf-proc/27/t1/abstr.html

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Publication Details

Journal
Electronic Journal of Differential Equations
Published
2024-08-20
DOI
https://doi.org/10.58997/ejde.conf.27.t1
Primary Topic
HIV Research and Treatment
Type
article
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article

On drug therapy for an HIV infection age model with cellular and immune delays

Nicoleta Tarfulea
Electronic Journal of Differential Equations
HIV Research and Treatment
article

On drug therapy for an HIV infection age model with cellular and immune delays

Nicoleta Tarfulea
article en

Abstract

We study the effectiveness of drug therapy for an HIV infection age mathematical model that considers both virus-to-cell and cell-to-cell infections, as well as the immune response. As expected, in the presence of perfect inhibitors, the populations of infected cells, virus, and effector cells decay exponentially to zero. When protease inhibitors are used, the production of infectious virions is diminished, as demonstrated in our drug therapy model. We begin our model analysis by proving the positivity and boundedness of the solutions, which are necessary conditions for the model's well-posedness. Our main result shows that, under a certain condition, both the infected cell population and the infectious virus decay exponentially to zero. For more information see https://ejde.math.txstate.edu/conf-proc/27/t1/abstr.html

Electronic Journal of Differential Equations(Conference 27)
Purdue University Northwest (US)
Good health and well-being
Openalex Percentile: Top 88%
HIV Research and Treatment
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