Cyclic‐di‐GMP induces inflammation and acute lung injury through direct binding to MD2
These results reveal that extracellular CDG induces lung injury through direct interaction with MD2 and activation of the TLR4 signalling pathway, providing valuable insights into bacteria-induced ALI mechanisms and new therapeutic approaches for the treatment of bacterial co-infection in COVID-19 patients.
Authors
- Chenchen Qian
- Guang Liang (ORCID: https://orcid.org/0000-0002-8278-849X)
- Weiyang Tang
- Xin Liu (ORCID: https://orcid.org/0009-0006-2118-3549)
- Zhe Wang (ORCID: https://orcid.org/0000-0001-6271-9692)
- Weiwei Zhu (ORCID: https://orcid.org/0000-0002-9969-2232)
- Bo Jin (ORCID: https://orcid.org/0000-0001-7277-1937)
- Yi Wang (ORCID: https://orcid.org/0009-0000-2861-9831)
- Yong Xu
- Yuyang Zhang (ORCID: https://orcid.org/0009-0004-5699-4144)
- Jiong Wang
Institutions
- Hangzhou Normal University (CN)
- Wenzhou Medical University (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1002/ctm2.1744
- Citations
- 7
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- National Natural Science Foundation of China