Targeting <i>Gsk3a</i> reverses immune evasion to enhance immunotherapy in hepatocellular carcinoma
We identified a potential HCC immune evasion target, <i>Gsk3a</i>, through CRISPR screening. <i>Gsk3a</i> induces neutrophil recruitment and NETs formation through the intermediate molecule LRG1, leading to the inhibition of CTLs function. Targeting <i>Gsk3a</i> can enhance CTLs function and improve the efficacy of ICIs.
Authors
- Jixuan Chen
- Xiaotian Shen (ORCID: https://orcid.org/0000-0001-5552-7473)
- Junjie Pan (ORCID: https://orcid.org/0000-0002-7570-6927)
- Sun‐Zhe Xie
- Yiran Chen (ORCID: https://orcid.org/0000-0002-1486-8412)
- Lun–Xiu Qin (ORCID: https://orcid.org/0000-0003-4805-8239)
- Zhenchao Chen
- Lu Lu (ORCID: https://orcid.org/0000-0002-2255-0391)
- Yitong Li (ORCID: https://orcid.org/0000-0003-4932-6987)
- Xin Zheng (ORCID: https://orcid.org/0009-0000-7333-0287)
- Luyu Yang
- Jiaqi Meng
- Wenwei Zhu (ORCID: https://orcid.org/0000-0002-0305-1191)
- Bolun Zhu
- Hao Wang (ORCID: https://orcid.org/0000-0002-5270-9463)
Institutions
- Shanghai Third People's Hospital (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1136/jitc-2024-009642
- Citations
- 16
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 6.70