Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension
Our integrative systems biology approach to dissect the PAH lung transcriptome uncovered asporin as a novel protective target with therapeutic potential in PAH.
Authors
- Katie A. Lutz (ORCID: https://orcid.org/0000-0002-9554-7679)
- Mélanie Eyries (ORCID: https://orcid.org/0000-0003-1911-6698)
- Stefan Gräf (ORCID: https://orcid.org/0000-0002-1315-8873)
- Micheala A. Aldred (ORCID: https://orcid.org/0000-0002-7390-9181)
- Lloyd L. Liang (ORCID: https://orcid.org/0009-0001-9999-9103)
- Mansoureh Eghbali (ORCID: https://orcid.org/0000-0002-6252-9976)
- Nicholas W. Morrell (ORCID: https://orcid.org/0000-0001-5700-9792)
- Florent Soubrier (ORCID: https://orcid.org/0000-0003-2571-7932)
- Frédéric Perros (ORCID: https://orcid.org/0000-0001-7730-2427)
- Brenda Wong (ORCID: https://orcid.org/0000-0002-0971-9789)
- Richard C. Trembath (ORCID: https://orcid.org/0000-0003-0550-3400)
- Christopher J. Rhodes (ORCID: https://orcid.org/0000-0002-4962-3204)
- William C. Nichols (ORCID: https://orcid.org/0000-0003-1242-9237)
- Adam J. Brownstein (ORCID: https://orcid.org/0009-0009-9900-2690)
- Arjun Vadgama (ORCID: https://orcid.org/0009-0000-0124-7193)
- Soban Umar (ORCID: https://orcid.org/0000-0001-8036-3079)
- Rubin M. Tuder (ORCID: https://orcid.org/0000-0001-9923-607X)
- Tae-Hwi Linus Schwantes-An (ORCID: https://orcid.org/0000-0001-6387-0095)
- Mark W. Geraci (ORCID: https://orcid.org/0000-0002-2280-3424)
- Rajan Saggar (ORCID: https://orcid.org/0000-0002-5536-5934)
- Grégoire Ruffenach (ORCID: https://orcid.org/0000-0001-6419-4332)
- Lejla Medzikovic
- David‐Alexandre Trégouët (ORCID: https://orcid.org/0000-0001-9084-7800)
- Laila Aryan (ORCID: https://orcid.org/0000-0002-9154-5342)
- David Montani (ORCID: https://orcid.org/0000-0002-9358-6922)
- Jason Hong (ORCID: https://orcid.org/0000-0002-5062-8926)
- Ankit A. Desai (ORCID: https://orcid.org/0000-0001-6427-616X)
- Min Li (ORCID: https://orcid.org/0009-0002-8915-7145)
- Robert S. Stearman (ORCID: https://orcid.org/0000-0002-7628-7066)
- Michael W. Pauciulo (ORCID: https://orcid.org/0000-0002-2141-2966)
- Xia Yang (ORCID: https://orcid.org/0000-0002-3971-038X)
- Zeyneb Kurt (ORCID: https://orcid.org/0000-0003-3186-8091)
- Martin R. Wilkins (ORCID: https://orcid.org/0000-0003-3926-1171)
- Wasila Sun (ORCID: https://orcid.org/0009-0009-6419-5162)
- Richard Channick
- Elizabeth A. Mickler
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Cincinnati Children's Hospital Medical Center (US)
- University of Colorado Hospital (US)
- Inserm (FR)
- University of California, Los Angeles (US)
- University of Pittsburgh (US)
- King's College London (GB)
- Université Paris-Saclay (FR)
- University of California System (US)
- Northumbria University (GB)
- Sorbonne Université (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hospices Civils de Lyon (FR)
- Lung Institute (US)
- Bordeaux Population Health (FR)
- Maine Farmland Trust (US)
- Hôpital Marie Lannelongue (FR)
- Anna Needs Neuroblastoma Answers (US)
- Pitié-Salpêtrière Hospital (FR)
- Laboratoire de recherche en cardiovasculaire, métabolisme, diabétologie et nutrition (FR)
- Bicêtre Hospital (FR)
- University of Colorado Anschutz Medical Campus (US)
- Indiana University – Purdue University Indianapolis (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Circulation
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1161/circulationaha.124.069864
- Citations
- 20
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.38
Funders
- American Heart Association
- American Thoracic Society
- Vanderbilt University
- Cleveland Clinic
- British Heart Foundation
- National Institutes of Health
- University of California, San Diego
- University of California, San Francisco
- National Heart, Lung, and Blood Institute