The Proteogenomics of Prostate Cancer Radioresistance
Radiation is standard of care in prostate cancer. Yet, we have little understanding of its failure. We demonstrate a new paradigm that radioresistance is fractionation specific and identified POLQ as a radioresistance modulator.
Authors
- Roni Haas (ORCID: https://orcid.org/0000-0003-1505-2965)
- Paul C. Boutros (ORCID: https://orcid.org/0000-0003-0553-7520)
- Enya H.W. Ong (ORCID: https://orcid.org/0000-0002-2591-7910)
- Dennis J.J. Poon
- Stanley K. Liu (ORCID: https://orcid.org/0000-0001-6851-0857)
- Pek Lim Chu
- Takafumi N. Yamaguchi (ORCID: https://orcid.org/0000-0003-1082-3871)
- Eugenia L.L. Yeo (ORCID: https://orcid.org/0000-0002-3639-7404)
- Vladimir Ignatchenko (ORCID: https://orcid.org/0009-0007-7457-7274)
- Benjamin Carlin (ORCID: https://orcid.org/0000-0002-9360-9143)
- Thomas Kislinger (ORCID: https://orcid.org/0000-0003-3525-5540)
- Natalie J. Kurganovs (ORCID: https://orcid.org/0000-0002-8555-5528)
- Shu Tao (ORCID: https://orcid.org/0000-0001-5177-6771)
- Yash Patel (ORCID: https://orcid.org/0000-0003-3113-7010)
- Andrew Loblaw (ORCID: https://orcid.org/0000-0002-4883-1781)
- Boon Hao Hong (ORCID: https://orcid.org/0000-0002-2822-7480)
- Beth K. Neilsen (ORCID: https://orcid.org/0000-0002-4859-6486)
- Julie Livingstone (ORCID: https://orcid.org/0000-0002-8424-3768)
- Geoff S. Higgins (ORCID: https://orcid.org/0000-0003-3072-909X)
- Chenghao Zhu (ORCID: https://orcid.org/0000-0003-1674-4533)
- Amar U. Kishan (ORCID: https://orcid.org/0000-0002-4836-8483)
- Melvin L.K. Chua (ORCID: https://orcid.org/0000-0002-1648-1473)
- Rupert Hugh-White (ORCID: https://orcid.org/0000-0003-3351-8925)
- Kah Min Tan (ORCID: https://orcid.org/0009-0000-7535-8734)
- Danny Vesprini (ORCID: https://orcid.org/0000-0001-9714-2782)
- Yuan Zhe Bugh
- Gavin Frame (ORCID: https://orcid.org/0009-0004-2924-134X)
- Wenyan Zhao
- Shahbaz Khan
- Michelle R. Downes (ORCID: https://orcid.org/0000-0002-4528-3724)
- Celestia P.X. Yeo
Institutions
- Sunnybrook Health Science Centre (CA)
- University Health Network (CA)
- University of California, Los Angeles (US)
- University of Toronto (CA)
- Health Sciences Centre (CA)
- Princess Margaret Cancer Centre (CA)
- University of Oxford (GB)
- City of Hope (US)
- Duke-NUS Medical School (SG)
- National Cancer Centre Singapore (SG)
- Sunnybrook Research Institute
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0292
- Citations
- 3
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.26
Funders
- U.S. Department of Defense
- Prostate Cancer Foundation
- Movember Foundation
- Duke-NUS Medical School
- Sunnybrook Foundation
- Prostate Cancer Canada
- Cancer Research UK
- University of Toronto
- Instituto Tecnológico de Costa Rica
- National Institutes of Health
- Medical Research Council
- National Medical Research Council
- U.S. National Library of Medicine