Smooth muscle-specific deletion of cellular communication network factor 2 causes severe aorta malformation and atherosclerosis
This study identifies CCN2 as a major constituent of the normal artery wall, critical in regulating SMC differentiation and aorta integrity and possessing a protective role against atherosclerosis development. These findings underscore the need for further investigation into the potential effects of anti-CCN2-based therapies on the vasculature.
Authors
- Lars Melholt Rasmussen (ORCID: https://orcid.org/0000-0001-5795-4794)
- Lasse Bach Steffensen (ORCID: https://orcid.org/0000-0001-6353-4227)
- Marta Ruiz‐Ortega (ORCID: https://orcid.org/0000-0002-1495-6535)
- Sebastian Albinsson (ORCID: https://orcid.org/0000-0001-6936-3967)
- Maria Bloksgaard (ORCID: https://orcid.org/0000-0002-4474-9553)
- Daniel F.J. Ketelhuth (ORCID: https://orcid.org/0000-0002-0087-116X)
- Didde R. Hansen (ORCID: https://orcid.org/0000-0002-6609-7795)
- Roel Goldschmeding (ORCID: https://orcid.org/0000-0002-5471-1153)
- Andrietta Grentzmann (ORCID: https://orcid.org/0000-0003-2007-8457)
- Gerard Pasterkamp (ORCID: https://orcid.org/0000-0001-5345-1022)
- Jes S. Lindholt (ORCID: https://orcid.org/0000-0001-9536-4488)
- Martin Overgaard (ORCID: https://orcid.org/0000-0003-2277-590X)
- Grith Lykke Sørensen (ORCID: https://orcid.org/0000-0002-5273-1097)
- Bartosz Pilecki (ORCID: https://orcid.org/0000-0001-8636-2245)
- Boye L. Jensen (ORCID: https://orcid.org/0000-0001-7607-213X)
- Jannik Hjortshøj Larsen (ORCID: https://orcid.org/0000-0001-7408-6968)
- Hans Christian Beck (ORCID: https://orcid.org/0000-0002-7763-3637)
- Michal Mokrý (ORCID: https://orcid.org/0000-0002-5298-4852)
- Charles Pyke (ORCID: https://orcid.org/0000-0002-7286-5009)
- Andrew Leask (ORCID: https://orcid.org/0000-0003-2832-283X)
- Jane Stubbe (ORCID: https://orcid.org/0000-0002-2703-453X)
- Caroline A. Lindegaard (ORCID: https://orcid.org/0009-0007-4708-0924)
- Raúl R Rodriguez-Díez
- Julie S Hegelund
- Camilla S Hansen
- Cecilie M Andersson
- Matilde K Pedersen
Institutions
- Universidad Complutense de Madrid (ES)
- University of Southern Denmark (DK)
- Lund University (SE)
- Novo Nordisk (Denmark) (DK)
- Heidelberg University (DE)
- Odense University Hospital (DK)
- University Hospital Heidelberg (DE)
- University Medical Center Utrecht (NL)
- University of Saskatchewan (CA)
- Hospital Universitario Fundación Jiménez Díaz (ES)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1093/cvr/cvae174
- Citations
- 2
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Danish Diabetes Academy
- Danmarks Frie Forskningsfond
- Syddansk Universitet
- Novo Nordisk Fonden
- Simon Fougner Hartmanns Familiefond
- Centre for Individualised Medicine in Arterial Diseases