Promotion of hepatocellular carcinoma stemness and progression by abnormal spindle-like microcephaly-associated protein via the Wnt/β-catenin pathway
These findings suggest that <i>ASPM</i> promotes HCC stemness and progression through the Wnt/β-catenin pathway. Targeting <i>ASPM</i> or the Wnt/β-catenin pathway may be a promising strategy to prevent HCC chemoresistance and recurrence, ultimately improving patient prognosis.
Authors
- Wenlong Zhai (ORCID: https://orcid.org/0000-0003-2559-2105)
- Ying Xiang (ORCID: https://orcid.org/0000-0001-9165-3346)
- Ruo Feng
- Ralf Weiskirchen (ORCID: https://orcid.org/0000-0003-3888-0931)
- Gaojie Li
- Jiyao Yang
Institutions
- Zhengzhou University (CN)
- Universitätsklinikum Aachen (DE)
- First Affiliated Hospital of Zhengzhou University (CN)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Journal of Gastrointestinal Oncology
- Published
- 2024-08-01
- DOI
- https://doi.org/10.21037/jgo-24-406
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Massachusetts Department of Agricultural Resources