Exploring the therapeutic potential of simvastatin in pancreatic neuroendocrine neoplasms: insights into cell cycle regulation and apoptosis
Our study highlights SIM as a promising candidate for pNEN treatment by inducing cell cycle arrest or apoptosis, potentially through the p53 and MAPK pathways. Further research is warranted to fully elucidate SIM's mechanisms of action and evaluate its therapeutic potential in clinical settings.
Authors
- Lijun Yan (ORCID: https://orcid.org/0000-0001-7863-0449)
- Qiyun Tang (ORCID: https://orcid.org/0000-0002-8354-5406)
- Jinhao Chen (ORCID: https://orcid.org/0009-0006-3272-0135)
- Mujie Ye (ORCID: https://orcid.org/0000-0002-5363-2752)
- Yuan Zhong (ORCID: https://orcid.org/0000-0001-9881-3509)
- Chunhua Hu (ORCID: https://orcid.org/0000-0002-8172-2202)
- Ping Yu
- Xiaoting Shi (ORCID: https://orcid.org/0000-0001-8270-2820)
- Feiyu Lu
Institutions
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2024-08-01
- DOI
- https://doi.org/10.21037/tcr-24-363
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Massachusetts Department of Agricultural Resources