Enantioselective Oxidative Homocoupling of 2-Oxindoles with a Chiral Bisguanidinium Hypoiodite Catalyst
Abstract The bisoxindole motif is present in a variety of biologically active compounds. Here, we report an enantioselective oxidative homocoupling reaction of 2-oxindoles in the presence of a chiral bisguanidinium hypoiodite catalyst, providing access to the corresponding optically active bisoxindoles in excellent yields and with moderate to high diastereo- and enantioselectivities.
Authors
- Kota Sugimoto
- Minami Odagi (ORCID: https://orcid.org/0000-0002-0334-3565)
- Choon‐Hong Tan (ORCID: https://orcid.org/0000-0003-3190-7855)
- Io Mori
- Kazuo Nagasawa
- Xu Ban
- Yuta Shimizu
Institutions
- Nanyang Technological University (SG)
- Henan Normal University (CN)
- Tokyo University of Agriculture and Technology (JP)
Publication Details
- Journal
- Synlett
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1055/s-0043-1775056
- Citations
- 3
- Primary Topic
- Oxidative Organic Chemistry Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.75
Funders
- Japan Society for the Promotion of Science