TFE3‐rearranged nonmelanotic renal PEComa: a case series expanding their phenotypic and fusion landscape
This study highlights the morphologic and genetic diversity of TFE3-rearranged primary renal PEComas and underlines the value of surrogate TFE3 immunohistochemistry in identifying them. The lack of PAX8 and keratin expression represents the mainstay for distinguishing these tumours from MiTF-associated renal cell carcinomas. In addition, we report rare (ZC3H4, RBMX) and novel (MED15) TFE3 fusion partners in PEComa.
Authors
- Sean R. Williamson (ORCID: https://orcid.org/0000-0002-3898-1460)
- Eddie Fridman (ORCID: https://orcid.org/0000-0002-0317-7085)
- Kiril Trpkov (ORCID: https://orcid.org/0000-0003-3142-8846)
- Christoph Schubart (ORCID: https://orcid.org/0000-0003-0084-9330)
- Abbas Agaimy (ORCID: https://orcid.org/0000-0002-0445-8161)
- Andres Martin Acosta (ORCID: https://orcid.org/0000-0001-8817-6331)
- Katrina Collins (ORCID: https://orcid.org/0000-0002-9603-6731)
- Liang Cheng (ORCID: https://orcid.org/0000-0001-6049-5293)
- Arndt Hartmann
Institutions
- Cleveland Clinic (US)
- Tel Aviv University (IL)
- University of Calgary (CA)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Brown University (US)
- Sheba Medical Center (IL)
- Calgary Laboratory Services (CA)
- Comprehensive Cancer Center Erlangen (DE)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Histopathology
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1111/his.15304
- Citations
- 16
- Primary Topic
- Tuberous Sclerosis Complex Research
- Type
- article
- Field-Weighted Citation Impact
- 5.22