Predominance of Dengue Virus Serotype-1/Genotype-I in Eastern and Southeastern Ethiopia
We determined the dengue virus (DENV) serotypes and genotypes in archived serum samples that were collected during the 2014-2016 and 2021 dengue outbreaks in Dire Dawa City and the Somali region in Ethiopia. DENV serotype 1 (DENV-1) was predominant followed by DENV serotype 2 (DENV-2). Thirteen of the DENV-1 strains were assigned to Genotype-I, while the remaining two were found to be Genotype-III. All three DENV-2 strains were assigned the Cosmopolitan Genotype. The DENV strains responsible for the outbreaks are genetically closely related to the DENV strains that circulated in neighboring and Asian countries. The findings also showed continued local transmission of a monophyletic lineage and a co-circulation of DENV-1 and DENV-2 during the outbreaks. There is a need to strengthen DENV genomic surveillance capacity for the early detection of circulating serotypes, and prevent devastating consequences of future outbreaks due to the co-circulation of different serotypes.
Authors
- Huachen Zhu (ORCID: https://orcid.org/0000-0003-2711-0501)
- Anne L Piantadosi (ORCID: https://orcid.org/0000-0002-5942-1534)
- Mesfin Wossen (ORCID: https://orcid.org/0000-0002-1689-5801)
- Mesfin Mengesha Tsegaye (ORCID: https://orcid.org/0000-0002-7756-9110)
- Dessalegn Abeje Tefera (ORCID: https://orcid.org/0000-0001-8693-6501)
- Andargachew Mulu (ORCID: https://orcid.org/0000-0003-2862-0175)
- Dawit Hailu Alemayehu (ORCID: https://orcid.org/0000-0002-4118-8260)
- Alemseged Abdissa (ORCID: https://orcid.org/0000-0003-3798-5037)
- Tamirayehu Seyoum Woldemichael
- Tesfaye Gelanew (ORCID: https://orcid.org/0000-0002-0696-3786)
- Adamu Tayachew (ORCID: https://orcid.org/0000-0001-6338-9824)
- Gadissa Gutema (ORCID: https://orcid.org/0000-0002-6117-1589)
- Adane Mihret
- Asefa Konde Korkiso
- Yoseph Asrat Temre
- Daniel Tsega Gebretsion
- Bethlehem Adnew Getaneh
- Eleni Kidane Abera
- Mengistu Biru Tessema
- Admikew Agunie Asfaw
Institutions
- Emory University (US)
- Ethiopian Public Health Institute (ET)
- Armauer Hansen Research Institute (ET)
- University of Hong Kong (HK)
Publication Details
- Journal
- Viruses
- Published
- 2024-08-21
- DOI
- https://doi.org/10.3390/v16081334
- Citations
- 4
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 2.17