The Impact of Fentanyl on the Effective Dose of Remimazolam-Induced Sedation in Elderly Female Patients: An Up-and-Down Sequential Allocation Trial
This study provides compelling evidence that the administration of 1 μg/kg of fentanyl significantly reduces the required sedative dose of remimazolam by approximately 30% during induction in elderly patients. Importantly, the concomitant use of 1 μg/kg of fentanyl does not increase the risk of adverse effects such as hypotension, respiratory depression.
Authors
- Xiaoyun Dong (ORCID: https://orcid.org/0000-0003-4850-4358)
- Weilong Wang (ORCID: https://orcid.org/0000-0001-6280-8118)
- Zhen-feng Zhou (ORCID: https://orcid.org/0000-0002-3213-0331)
- Xiaodong Huang (ORCID: https://orcid.org/0000-0002-1496-2409)
- Jia-Bao Chen
- Jin Zhou
Institutions
- Hangzhou Women’s Hospital (CN)
- Zhejiang Provincial People's Hospital (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2024-08-01
- DOI
- https://doi.org/10.2147/dddt.s473662
- Citations
- 10
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 6.42