Thymol Protects against 5-Fluorouracil-Induced Hepatotoxicity via the Regulation of the Akt/GSK-3β Pathway in In Vivo and In Silico Experimental Models
Our research is the first to shed light on thymol's potential protective effect against 5-FU- induced hepatotoxicity by inhibiting oxidative and apoptotic pathways and modulating the Akt/ GSK-3β as well as p44/42 MAPK (ERK1/2) signaling pathways.
Authors
- Hanaa N. Alajami
- Yasmen F. Mahran
- Amira M. Badr (ORCID: https://orcid.org/0000-0003-3983-868X)
- Nouf T. Al‐Damry
- Nervana Bayoumy (ORCID: https://orcid.org/0000-0002-4285-9097)
- Elshaymaa I. Elmongy (ORCID: https://orcid.org/0000-0003-1160-5040)
- Sahar Soliman (ORCID: https://orcid.org/0000-0002-0648-0979)
- Layla A. Al‐Kharashi (ORCID: https://orcid.org/0000-0003-3171-771X)
Institutions
- Ain Shams University (EG)
- Sam Houston State University (US)
- King Saud University (SA)
- Helwan University (EG)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2024-08-21
- DOI
- https://doi.org/10.3390/ph17081094
- Citations
- 11
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 5.14
Funders
- King Saud University