Plexin C1 influences immune response to intracellular LPS and survival in murine sepsis
These results elucidate a previously unknown mechanism for PLXNC1 suppressing excessive noncanonical inflammasome activity and offer a new potential target for treatment of sepsis with its detrimental effects.
Authors
- Valbona Mirakaj (ORCID: https://orcid.org/0000-0002-6907-6455)
- Andreas Körner (ORCID: https://orcid.org/0000-0002-9643-7498)
- Claudia Eggstein
- Marius Keller (ORCID: https://orcid.org/0000-0002-5810-8845)
- Linyan Tang (ORCID: https://orcid.org/0000-0003-3427-1573)
- Peter Rosenberger (ORCID: https://orcid.org/0000-0002-6925-4485)
- Alice Bernard (ORCID: https://orcid.org/0000-0003-1803-7883)
Institutions
- University of Tübingen (DE)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1186/s12929-024-01074-x
- Citations
- 4
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Deutsche Forschungsgemeinschaft