Experimental Use of Common Marmosets (<i>Callithrix jacchus</i>) in Preclinical Trials of Antiviral Vaccines
Common marmoset (<i>Callithrix jacchus</i>, CM) is a New World primate species that is of interest for preclinical trials of immunobiological products. In this study, we describe the approaches to long-term laboratory breeding and maintenance of CMs. We also establish the reference values of the main complete blood count and serum chemistry parameters evaluated during preclinical trials of immunobiological products and describe the histological characteristics of CM lymphoid organs during the development of post-vaccination immune response. We show that CMs bred in laboratory conditions excluding background infectious pathology are a relevant model that allows for a high degree of reliability in characterizing the safety and immunogenicity profile of antiviral vaccines during preclinical trials.
Authors
- Aydar A. Ishmukhametov (ORCID: https://orcid.org/0000-0001-6130-4145)
- Соцкова Светлана Евгеньевна (ORCID: https://orcid.org/0000-0003-4527-8631)
- Aleksandr S. Lunin (ORCID: https://orcid.org/0000-0003-4624-2593)
- Ilya Gordeychuk (ORCID: https://orcid.org/0000-0002-4551-7535)
- Tatiana V. Gulyaeva (ORCID: https://orcid.org/0000-0003-2486-6952)
- Olga Gancharova (ORCID: https://orcid.org/0000-0001-7441-1062)
- Alexander Moroz (ORCID: https://orcid.org/0000-0003-4866-6517)
- E. A. Korduban
- Amir I. Tukhvatulin (ORCID: https://orcid.org/0000-0001-8506-2339)
- Darya Avdoshina (ORCID: https://orcid.org/0000-0001-8168-5969)
- Ekaterina Bayurova
- S. A. Gulyaev
- Alla Zhitkevich
Institutions
- Russian Academy of Sciences (RU)
- Sechenov University (RU)
- Lomonosov Moscow State University (RU)
- Ministry of Health of the Russian Federation (RU)
- Moscow State University (TJ)
- Centre for Research and Development (ZW)
Publication Details
- Journal
- Acta Naturae
- Published
- 2024-08-21
- DOI
- https://doi.org/10.32607/actanaturae.27372
- Citations
- 2
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.48