Research on the Anti-Fatigue Effects and Mechanisms of Arecoline in Sleep-Deprived Mice
This study demonstrates that arecoline has anti-fatigue activity, and the specific mechanisms are associated with elevating glucose and lipid metabolism levels, relieving oxidative stress damage, inhibiting neuroinflammatory response, and regulating neurotransmitter levels and the Keap1/Nrf2/HO-1 signaling pathway. The research provides a new direction for arecoline's potential in preventing and improving fatigue.
Authors
- Jiameng Liu (ORCID: https://orcid.org/0000-0002-3709-531X)
- Danyang Wang (ORCID: https://orcid.org/0000-0003-3471-4231)
- Cong Lü (ORCID: https://orcid.org/0000-0002-9514-6867)
- Fengzhong Wang
- Jing Sun (ORCID: https://orcid.org/0000-0002-3569-7093)
- Yuan Sun (ORCID: https://orcid.org/0009-0009-0518-9336)
- Bei Fan (ORCID: https://orcid.org/0000-0001-8981-8420)
Institutions
- Shanxi Agricultural University (CN)
- Institute of Food Science and Technology (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Sanya University (CN)
Publication Details
- Journal
- Nutrients
- Published
- 2024-08-21
- DOI
- https://doi.org/10.3390/nu16162783
- Citations
- 10
- Primary Topic
- Medicinal Plants and Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 2.34