7-Methylguanine Inhibits Colon Cancer Growth <i>in vivo</i>
7-Methylguanine (7-MG) is a natural inhibitor of poly(ADP-ribose) polymerase 1 and tRNA-guanine transglycosylase, the enzymatic activity of which is central for the proliferation of cancer cells. Recently, a number of preclinical tests have demonstrated the safety of 7-MG and a regimen of intragastric administration was established in mice. In the present work, the pharmacological activity of 7-MG was studied in BALB/c and BALB/c nude mice with transplanted tumors. It was found that 7-MG effectively penetrates tumor tissue and suppresses colon adenocarcinoma growth in the Akatol model, as well as in a xenograft model with human HCT116 cells.
Authors
- Tatiana Gor’kova
- Elena Antoshina
- Louay Abo Qoura (ORCID: https://orcid.org/0000-0001-5391-5077)
- Yu. A. Zolotarev (ORCID: https://orcid.org/0000-0001-8342-5888)
- Timur I. Fetisov (ORCID: https://orcid.org/0000-0002-5082-9883)
- Vytas K. Švedas (ORCID: https://orcid.org/0000-0002-1664-0307)
- К. I. Kirsanov (ORCID: https://orcid.org/0000-0002-8599-6833)
- Vadim S. Pokrovsky (ORCID: https://orcid.org/0000-0003-4006-9320)
- I. Yu. Nagaev (ORCID: https://orcid.org/0000-0001-9301-103X)
- D. K. Nilov (ORCID: https://orcid.org/0000-0002-5067-7939)
- С. И. Шрам (ORCID: https://orcid.org/0000-0002-0331-5505)
- M. G. Yakubovskaya
- Lubov Trukhanova
Institutions
- Peoples' Friendship University of Russia (RU)
- Lomonosov Moscow State University (RU)
- Kurchatov Institute (RU)
- Kementerian Kesehatan Republik Indonesia (ID)
- Moscow State University (TJ)
Publication Details
- Journal
- Acta Naturae
- Published
- 2024-08-21
- DOI
- https://doi.org/10.32607/actanaturae.27422
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00