Gulf war illness: a tale of two genomes
BChE "adverse" variants significantly predicted GWI severity (β(SE) = 23.4(11.4), p = 0.046), as did mt haplogroup U (β(SE) = 36.4(13.6), p = 0.010). In a model including both, BChE was no longer significant, but mt haplogroup U retained significance (β(SE) = 36.7(13.0), p = 0.007). This is the first study to show that mitochondrial genetics are tied to GWI severity in Gulf-deployed veterans. Other data affirm a tie to nuclear genetics, making GWI indeed a "tale of two genomes."
Authors
- Bruce Miller
- Richard I. Kelley (ORCID: https://orcid.org/0000-0002-5508-7145)
- Beatrice A. Golomb (ORCID: https://orcid.org/0000-0002-4454-0485)
- Junhee Han (ORCID: https://orcid.org/0000-0001-5736-8752)
- Leeann Bui
Institutions
- Boston Children's Hospital (US)
- Santa Clara Valley Medical Center (US)
- University of California San Diego (US)
Publication Details
- Journal
- BMC Research Notes
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1186/s13104-024-06871-z
- Citations
- 5
- Primary Topic
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- U.S. Department of Defense
- Congressionally Directed Medical Research Programs