Optimization of a DiCre recombinase system with reduced leakage for conditional genome editing of Cryptosporidium
A DiCre conditional gene knockout system for Cryptosporidium with good cleavage efficiency and reduced leaky activity has been successfully established.
Authors
- Yaqiong Guo (ORCID: https://orcid.org/0000-0001-9958-1295)
- Yaoyu Feng (ORCID: https://orcid.org/0000-0002-8380-1246)
- Jinli Li (ORCID: https://orcid.org/0000-0002-3556-9200)
- Huimin Liu (ORCID: https://orcid.org/0000-0003-4823-3420)
- Lihua Xiao (ORCID: https://orcid.org/0000-0001-8532-2727)
- Rui Xu (ORCID: https://orcid.org/0000-0001-8720-8979)
- Na Li (ORCID: https://orcid.org/0000-0003-0193-1475)
- Yue Huang (ORCID: https://orcid.org/0009-0007-7291-5866)
- Heng You
- S. Pei
Institutions
- South China Agricultural University (CN)
- China Animal Disease Control Center (CN)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1186/s13071-024-06431-1
- Citations
- 4
- Primary Topic
- Parasitic Infections and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 2.06
Funders
- National Natural Science Foundation of China
- Jinan University
- Higher Education Discipline Innovation Project
- National Key Research and Development Program of China