A neonatal mouse model of meconium peritonitis generated using human meconium slurry
In this study, we generated a neonatal mouse model of meconium peritonitis through intraperitoneal administration of human meconium slurry. We clarified that the pathogenic agent in meconium slurry is mainly a digestive enzyme, and that the systemic responses elicited by meconium slurry were distinct from those in a neonatal sepsis mouse model. As our mouse model is simple and highly reproducible, it is useful for elucidating the pathophysiology of meconium peritonitis.
Authors
- Kandai Nozu (ORCID: https://orcid.org/0000-0002-0290-3137)
- Takumi Kido
- Yu Masuda
- Mariko Ashina
- Keisuke Shirai (ORCID: https://orcid.org/0000-0002-1403-8128)
- Kazumichi Fujioka (ORCID: https://orcid.org/0000-0002-9913-6447)
- Yuki Nakata (ORCID: https://orcid.org/0009-0007-9460-2684)
- Yukihito Imagawa
Institutions
- Kobe University (JP)
Publication Details
- Journal
- Pediatric Research
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1038/s41390-024-03470-3
- Citations
- 1
- Primary Topic
- Pediatric Pain Management Techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- Kawano Masanori Memorial Public Interest Incorporated Foundation
- Japan Foundation for Pediatric Research
- Lastentautien Tutkimussäätiö
- Japan Society for the Promotion of Science