The response to influenza vaccination is associated with DNA methylation-driven regulation of T cell innate antiviral pathways
Our findings indicate that 179 methylation sites can be combined as potential signatures to predict seroprotection. These sites were not only enriched for genes involved in the regulation of the RIG-I signaling pathway, as found previously, but also enriched for other genes associated with innate immunity to viruses and the transcription factor binding sites of BRD4, which is known to impact T cell memory. We propose a model to suggest that the RIG-I pathway and BRD4 could potentially be modulated to improve immunization strategies.
Authors
- Harry Pickering (ORCID: https://orcid.org/0000-0003-2348-5410)
- Wanding Zhou (ORCID: https://orcid.org/0000-0001-9126-1932)
- Matteo Pellegrini (ORCID: https://orcid.org/0000-0001-9355-9564)
- Ted M. Ross (ORCID: https://orcid.org/0000-0003-1947-7469)
- Elaine F. Reed (ORCID: https://orcid.org/0000-0002-3524-545X)
- Hongxiang Fu (ORCID: https://orcid.org/0000-0002-9873-8606)
- Liudmilla Rubbi
Institutions
- Children's Hospital of Philadelphia (US)
- University of California, Los Angeles (US)
- University of Georgia (US)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1186/s13148-024-01730-x
- Citations
- 5
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 1.20
Funders
- U.S. Department of Health and Human Services
- University of Georgia
- Georgia Research Alliance
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- National Center for Advancing Translational Sciences