Boundary-based registration improves sensitivity for detecting hypoperfusion in sporadic frontotemporal lobar degeneration
ASL is sensitive to distinct regions of hypoperfusion in patient participants relative to controls, and in patients with sFTLD-TDP relative to sFTLD-tau, and decreasing perfusion is associated with increasing disease severity, at least in sFTLD-TDP. BBR can register ASL-T1w images adequately for controls and patients.
Authors
- James C. Gee (ORCID: https://orcid.org/0000-0002-2258-0187)
- Philip A. Cook (ORCID: https://orcid.org/0000-0002-1985-8475)
- Corey T. McMillan (ORCID: https://orcid.org/0000-0002-7581-6405)
- Maria Luisa Gorno‐Tempini (ORCID: https://orcid.org/0000-0002-7426-7782)
- Murray Grossman (ORCID: https://orcid.org/0000-0002-7447-6218)
- Christopher A. Olm (ORCID: https://orcid.org/0000-0002-4858-2359)
- Emily Rogalskı (ORCID: https://orcid.org/0000-0002-6472-1363)
- Maria Luisa Mandelli (ORCID: https://orcid.org/0000-0002-2518-2520)
- Quinn Hlava
- Bradley F. Boeve (ORCID: https://orcid.org/0000-0002-4153-8187)
- Bradford Clark Dickerson (ORCID: https://orcid.org/0000-0002-5958-3445)
- Suzee E. Lee (ORCID: https://orcid.org/0009-0004-3295-6346)
- Sylvia Mihailescu
Institutions
- University of California, San Francisco (US)
- University of Chicago (US)
- Massachusetts General Hospital (US)
- Mayo Clinic in Arizona (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2024-08-21
- DOI
- https://doi.org/10.3389/fneur.2024.1452944
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Pennsylvania
- National Institutes of Health