Impact of SARS-CoV-2 Resistance to Antiviral Monoclonal Antibody Therapy on Neutralizing Antibody Response
Emerging drug resistance after SARS-CoV-2-specific mAb therapy led to a heightened host neutralizing antibody response to the mAb-resistant variant that was associated with eventual viral clearance. This demonstrates the interplay between the antiviral treatment-directed viral evolution and subsequent host immune response in viral clearance.
Authors
- Kara W Chew (ORCID: https://orcid.org/0000-0003-4865-4348)
- Rinki Deo
- Alan Landay (ORCID: https://orcid.org/0000-0001-9645-1356)
- Joseph J. Eron (ORCID: https://orcid.org/0000-0002-4938-0644)
- Carlee Moser (ORCID: https://orcid.org/0000-0001-5601-9112)
- Paul Klekotka
- Daniela Moïsi (ORCID: https://orcid.org/0000-0003-2326-7683)
- John W. Mellors (ORCID: https://orcid.org/0000-0002-3737-9742)
- Jonathan Z. Li (ORCID: https://orcid.org/0000-0001-9914-9662)
- Scott F. Sieg (ORCID: https://orcid.org/0000-0002-1769-8682)
- Amy Heaps (ORCID: https://orcid.org/0000-0003-4410-4007)
- Davey M. Smith (ORCID: https://orcid.org/0000-0003-3603-1733)
- Kelley C. Gordon
- Manish C. Choudhary (ORCID: https://orcid.org/0000-0002-3192-7840)
- Judith S. Currier (ORCID: https://orcid.org/0000-0003-4279-4737)
- Urvi M. Parikh (ORCID: https://orcid.org/0000-0002-4016-0629)
- Marc-Kendy Paul
Institutions
- University of North Carolina at Chapel Hill (US)
- Brigham and Women's Hospital (US)
- Rush University Medical Center (US)
- Harvard University (US)
- University of California, Los Angeles (US)
- Eli Lilly (United States) (US)
- University of Pittsburgh (US)
- University Hospitals of Cleveland (US)
- University of California San Diego (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Pathogens and Immunity
- Published
- 2024-08-21
- DOI
- https://doi.org/10.20411/pai.v9i2.718
- Citations
- 2
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.78
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases