Impact of SARS-CoV-2 Resistance to Antiviral Monoclonal Antibody Therapy on Neutralizing Antibody Response

Emerging drug resistance after SARS-CoV-2-specific mAb therapy led to a heightened host neutralizing antibody response to the mAb-resistant variant that was associated with eventual viral clearance. This demonstrates the interplay between the antiviral treatment-directed viral evolution and subsequent host immune response in viral clearance.

Authors

Institutions

Publication Details

Journal
Pathogens and Immunity
Published
2024-08-21
DOI
https://doi.org/10.20411/pai.v9i2.718
Citations
2
Primary Topic
SARS-CoV-2 and COVID-19 Research
Type
article
Field-Weighted Citation Impact
0.78

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Impact of SARS-CoV-2 Resistance to Antiviral Monoclonal Antibody Therapy on Neutralizing Antibody Response

Kara W Chew, Rinki Deo, Alan Landay, Joseph J. Eron et al.
2 citations
Pathogens and Immunity
SARS-CoV-2 and COVID-19 Research
0.78
article

Impact of SARS-CoV-2 Resistance to Antiviral Monoclonal Antibody Therapy on Neutralizing Antibody Response

Kara W Chew, Rinki Deo, Alan Landay, Joseph J. Eron, Carlee Moser, Paul Klekotka, Daniela Moïsi, John W. Mellors, Jonathan Z. Li, Scott F. Sieg, Amy Heaps, Davey M. Smith, Kelley C. Gordon, Manish C. Choudhary, Judith S. Currier, Urvi M. Parikh, Marc-Kendy Paul
article en
2 citations

Abstract

Emerging drug resistance after SARS-CoV-2-specific mAb therapy led to a heightened host neutralizing antibody response to the mAb-resistant variant that was associated with eventual viral clearance. This demonstrates the interplay between the antiviral treatment-directed viral evolution and subsequent host immune response in viral clearance.

Pathogens and ImmunityVol. 9(2)
University of North Carolina at Chapel Hill (US), Brigham and Women's Hospital (US), Rush University Medical Center (US), Harvard University (US), University of California, Los Angeles (US), Eli Lilly (United States) (US), University of Pittsburgh (US), University Hospitals of Cleveland (US), University of California San Diego (US), Case Western Reserve University (US)
National Institutes of Health, National Institute of Allergy and Infectious Diseases
Good health and well-being
Openalex Percentile: Top 28%
SARS-CoV-2 and COVID-19 Research
0.78
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.