Effects of Inonotus obliquus on ameliorating podocyte injury in ORG mice through TNF pathway and prediction of active compounds
The research based on UPLC-Q-TOF-MS analysis, network pharmacology and <i>in vivo</i> experiment suggested that the amelioration of IO on podocyte injury in ORG mice via its modulation on TNF signal. Triterpenoids were predicated as acting components.
Authors
- Le Gong (ORCID: https://orcid.org/0000-0002-8882-0278)
- Hui Liao (ORCID: https://orcid.org/0000-0001-6325-062X)
- Jing Liu (ORCID: https://orcid.org/0000-0001-5101-6510)
- Rongshan Li (ORCID: https://orcid.org/0000-0002-8082-4389)
- Wenyan Zhao (ORCID: https://orcid.org/0000-0002-2222-377X)
- Zhaodi Han (ORCID: https://orcid.org/0000-0001-7839-4896)
- Xinyu Wang (ORCID: https://orcid.org/0000-0002-9167-2077)
- Rui Wang (ORCID: https://orcid.org/0000-0003-3825-3620)
- Yani Xue
Institutions
- Shanxi Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-08-21
- DOI
- https://doi.org/10.3389/fphar.2024.1426917
- Citations
- 5
- Primary Topic
- Medicinal Plants and Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Shanxi Medical University